Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

ABSTRACT Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1). We utilize a mouse model of live-attenuated im...

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Main Authors: Weng M. Ng, Mehmet Sahin, Stefanie A. Krumm, Jeffrey Seow, Antra Zeltina, Karl Harlos, Guido C. Paesen, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2022-04-01
Serier:mBio
Fag:
arenavirus
glycoprotein
structure
antibody response
monoclonal antibody
antibody-mediated neutralization
Online adgang:https://journals.asm.org/doi/10.1128/mbio.02650-21
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