Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the viruses. As such, receptor-mimic...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Clark, Lars E., Mahmutovic, Selma, Raymond, Donald D., Dilanyan, Taleen, Koma, Takaaki, Manning, John T., Shankar, Sundaresh, Levis, Silvana C., Briggiler, Ana M., Enria, Delia A., Wucherpfennig, Kai W., Paessler, Slobodan, Abraham, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951886/
https://ncbi.nlm.nih.gov/pubmed/29760382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04271-z
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