ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma triglycerides (TGs) correlate strongly with plasma apolipoprotein C-III (ApoC-III) levels. Antisense oligonucleotides (ASOs) for ApoC-III reduce plasma TGs in primates and mice, but the underlying mechanism of...

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發表在:J Clin Invest
Main Authors: Gordts, Philip L.S.M., Nock, Ryan, Son, Ni-Huiping, Ramms, Bastian, Lew, Irene, Gonzales, Jon C., Thacker, Bryan E., Basu, Debapriya, Lee, Richard G., Mullick, Adam E., Graham, Mark J., Goldberg, Ira J., Crooke, Rosanne M., Witztum, Joseph L., Esko, Jeffrey D.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966320/
https://ncbi.nlm.nih.gov/pubmed/27400128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86610
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