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Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases

The potential for recombining intact polyketide synthase (PKS) modules has been extensively explored. Both enzyme-substrate and protein-protein interactions influence chimeric PKS activity, but their relative contributions are unclear. We now address this issue by studying a library of 11 bimodular...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Klaus, Maja, Ostrowski, Matthew P., Austerjost, Jonas, Robbins, Thomas, Lowry, Brian, Cane, David E., Khosla, Chaitan
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965586/
https://ncbi.nlm.nih.gov/pubmed/27246853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.730531
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