Distal Hydrogen-bonding Interactions in Ligand Sensing and Signaling by Mycobacterium tuberculosis DosS

Mycobacterium tuberculosis DosS is critical for the induction of M. tuberculosis dormancy genes in response to nitric oxide (NO), carbon monoxide (CO), or hypoxia. These environmental stimuli, which are sensed by the DosS heme group, result in autophosphorylation of a DosS His residue, followed by p...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Basudhar, Debashree, Madrona, Yarrow, Yukl, Erik T., Sivaramakrishnan, Santhosh, Nishida, Clinton R., Moënne-Loccoz, Pierre, Ortiz de Montellano, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965560/
https://ncbi.nlm.nih.gov/pubmed/27235395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.724815
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