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A DISTAL TYROSINE RESIDUE IS REQUIRED FOR LIGAND DISCRIMINATION IN DEVS FROM Mycobacterium tuberculosis
DevS is a heme-based sensor kinase required for sensing environmental conditions leading to non-replicating persistence in M. tuberculosis. Kinase activity is observed when the heme is ferrous 5-coordinate high-spin or 6-coordinate low-spin CO or NO complex, but is strongly inhibited in the oxy comp...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2666047/ https://ncbi.nlm.nih.gov/pubmed/18975917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801234w |
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