Structure-guided development of heterodimer-selective GPCR ligands

Crystal structures of G protein-coupled receptor (GPCR) ligand complexes allow a rational design of novel molecular probes and drugs. Here we report the structure-guided design, chemical synthesis and biological investigations of bivalent ligands for dopamine D(2) receptor/neurotensin NTS(1) recepto...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Hübner, Harald, Schellhorn, Tamara, Gienger, Marie, Schaab, Carolin, Kaindl, Jonas, Leeb, Laurin, Clark, Timothy, Möller, Dorothee, Gmeiner, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963535/
https://ncbi.nlm.nih.gov/pubmed/27457610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12298
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