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Structure-guided development of heterodimer-selective GPCR ligands
Crystal structures of G protein-coupled receptor (GPCR) ligand complexes allow a rational design of novel molecular probes and drugs. Here we report the structure-guided design, chemical synthesis and biological investigations of bivalent ligands for dopamine D(2) receptor/neurotensin NTS(1) recepto...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4963535/ https://ncbi.nlm.nih.gov/pubmed/27457610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12298 |
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