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Active-State Models of Ternary GPCR Complexes: Determinants of Selective Receptor-G-Protein Coupling
Based on the recently described crystal structure of the β(2) adrenergic receptor - G(s)-protein complex, we report the first molecular-dynamics simulations of ternary GPCR complexes designed to identify the selectivity determinants for receptor-G-protein binding. Long-term molecular dynamics simula...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3691126/ https://ncbi.nlm.nih.gov/pubmed/23826246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067244 |
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