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Ni-Catalyzed Enantioselective C-Acylation of α-Substituted Lactams
A new strategy for the catalytic enantioselective C-acylation to generate α-quaternary substituted lactams is reported. Ni-catalyzed three-component coupling of lactam enolates, benzonitriles, and aryl halides produce β-imino lactams that then afford β-keto lactams by acid hydrolysis. Use of a readi...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Am Chem Soc |
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| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2016
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4963289/ https://ncbi.nlm.nih.gov/pubmed/27373124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b02120 |
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