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Ni-Catalyzed Enantioselective C-Acylation of α-Substituted Lactams

A new strategy for the catalytic enantioselective C-acylation to generate α-quaternary substituted lactams is reported. Ni-catalyzed three-component coupling of lactam enolates, benzonitriles, and aryl halides produce β-imino lactams that then afford β-keto lactams by acid hydrolysis. Use of a readi...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Hayashi, Masaki, Bachman, Shoshana, Hashimoto, Satoshi, Eichman, Chad C., Stoltz, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963289/
https://ncbi.nlm.nih.gov/pubmed/27373124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b02120
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