Different promoter affinities account for specificity in MYC-dependent gene regulation

Enhanced expression of the MYC transcription factor is observed in the majority of tumors. Two seemingly conflicting models have been proposed for its function: one proposes that MYC enhances expression of all genes, while the other model suggests gene-specific regulation. Here, we have explored the...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Lorenzin, Francesca, Benary, Uwe, Baluapuri, Apoorva, Walz, Susanne, Jung, Lisa Anna, von Eyss, Björn, Kisker, Caroline, Wolf, Jana, Eilers, Martin, Wolf, Elmar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
Onderwerpen:
Cancer Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963202/
https://ncbi.nlm.nih.gov/pubmed/27460974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15161
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