Activation and repression by oncogenic Myc shape tumour-specific gene expression profiles

In mammalian cells, the Myc oncoprotein binds to thousands of promoters(1–4). During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes(1). In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and...

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Publicat a:Nature
Autors principals: Walz, Susanne, Lorenzin, Francesca, Morton, Jennifer, Wiese, Katrin E., von Eyss, Björn, Herold, Steffi, Rycak, Lukas, Dumay-Odelot, Hélène, Karim, Saadia, Bartkuhn, Marek, Roels, Frederik, Wuestefeld, Thorsten, Fischer, Matthias, Teichmann, Martin, Zender, Lars, Wei, Chia-Lin, Sansom, Owen, Wolf, Elmar, Eilers, Martin
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879323/
https://ncbi.nlm.nih.gov/pubmed/25043018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13473
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