Activation and repression by oncogenic Myc shape tumour-specific gene expression profiles

In mammalian cells, the Myc oncoprotein binds to thousands of promoters(1–4). During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes(1). In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Walz, Susanne, Lorenzin, Francesca, Morton, Jennifer, Wiese, Katrin E., von Eyss, Björn, Herold, Steffi, Rycak, Lukas, Dumay-Odelot, Hélène, Karim, Saadia, Bartkuhn, Marek, Roels, Frederik, Wuestefeld, Thorsten, Fischer, Matthias, Teichmann, Martin, Zender, Lars, Wei, Chia-Lin, Sansom, Owen, Wolf, Elmar, Eilers, Martin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879323/
https://ncbi.nlm.nih.gov/pubmed/25043018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13473
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