Activation and repression by oncogenic Myc shape tumour-specific gene expression profiles

In mammalian cells, the Myc oncoprotein binds to thousands of promoters(1–4). During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes(1). In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Walz, Susanne, Lorenzin, Francesca, Morton, Jennifer, Wiese, Katrin E., von Eyss, Björn, Herold, Steffi, Rycak, Lukas, Dumay-Odelot, Hélène, Karim, Saadia, Bartkuhn, Marek, Roels, Frederik, Wuestefeld, Thorsten, Fischer, Matthias, Teichmann, Martin, Zender, Lars, Wei, Chia-Lin, Sansom, Owen, Wolf, Elmar, Eilers, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879323/
https://ncbi.nlm.nih.gov/pubmed/25043018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13473
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