Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein

Precise modifications such as site mutation, codon replacement, insertion or precise targeted deletion are needed for studies of accurate gene function. The CRISPR/Cas9 system has been proved as a powerful tool to generate gene knockout and knockin animals. But the homologous recombination (HR)-dire...

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Detaylı Bibliyografya
Yayımlandı:RNA Biol
Asıl Yazarlar: Ma, Yuanwu, Chen, Wei, Zhang, Xu, Yu, Lei, Dong, Wei, Pan, Shuo, Gao, Shan, Huang, Xingxu, Zhang, Lianfeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2016
Konular:
Brief Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962809/
https://ncbi.nlm.nih.gov/pubmed/27163284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2016.1185591
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