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Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9
The CRISPR/Cas9 system has been proven to be an efficient gene-editing tool for genome modification of cells and organisms. Multiplex genetic engineering in rat holds a bright future for the study of complex disease. Here, we show that this system enables the simultaneous disruption of four genes (A...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3943732/ https://ncbi.nlm.nih.gov/pubmed/24598943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089413 |
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