Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System

Leptin receptor, which is encoded by the diabetes (db) gene and is highly expressed in the choroid plexus, regulatesenergy homeostasis, the balance between food intake and energy expenditure, fertility and bone mass. Here, using CRISPR/Cas9 technology, we created the leptin receptor knockout rat. Ho...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Bao, Dan, Ma, Yuanwu, Zhang, Xu, Guan, Feifei, Chen, Wei, Gao, Kai, Qin, Chuan, Zhang, Lianfeng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633582/
https://ncbi.nlm.nih.gov/pubmed/26537785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15942
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