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Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System
Leptin receptor, which is encoded by the diabetes (db) gene and is highly expressed in the choroid plexus, regulatesenergy homeostasis, the balance between food intake and energy expenditure, fertility and bone mass. Here, using CRISPR/Cas9 technology, we created the leptin receptor knockout rat. Ho...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4633582/ https://ncbi.nlm.nih.gov/pubmed/26537785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15942 |
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