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Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System

Leptin receptor, which is encoded by the diabetes (db) gene and is highly expressed in the choroid plexus, regulatesenergy homeostasis, the balance between food intake and energy expenditure, fertility and bone mass. Here, using CRISPR/Cas9 technology, we created the leptin receptor knockout rat. Ho...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Bao, Dan, Ma, Yuanwu, Zhang, Xu, Guan, Feifei, Chen, Wei, Gao, Kai, Qin, Chuan, Zhang, Lianfeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633582/
https://ncbi.nlm.nih.gov/pubmed/26537785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15942
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