Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein

Precise modifications such as site mutation, codon replacement, insertion or precise targeted deletion are needed for studies of accurate gene function. The CRISPR/Cas9 system has been proved as a powerful tool to generate gene knockout and knockin animals. But the homologous recombination (HR)-dire...

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Detalles Bibliográficos
Publicado en:RNA Biol
Main Authors: Ma, Yuanwu, Chen, Wei, Zhang, Xu, Yu, Lei, Dong, Wei, Pan, Shuo, Gao, Shan, Huang, Xingxu, Zhang, Lianfeng
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
Assuntos:
Brief Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962809/
https://ncbi.nlm.nih.gov/pubmed/27163284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2016.1185591
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