Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein

Precise modifications such as site mutation, codon replacement, insertion or precise targeted deletion are needed for studies of accurate gene function. The CRISPR/Cas9 system has been proved as a powerful tool to generate gene knockout and knockin animals. But the homologous recombination (HR)-dire...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:RNA Biol
Päätekijät: Ma, Yuanwu, Chen, Wei, Zhang, Xu, Yu, Lei, Dong, Wei, Pan, Shuo, Gao, Shan, Huang, Xingxu, Zhang, Lianfeng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2016
Aiheet:
Brief Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962809/
https://ncbi.nlm.nih.gov/pubmed/27163284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2016.1185591
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