KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma

PURPOSE: In patients with neuroblastoma (NB), treatment with anti-GD2 monoclonal antibody (mAb) directs natural killer (NK) cell–mediated antibody-dependent cellular cytotoxicity (ADCC) against tumor cells. However, tumor cytotoxicity is attenuated by ligation of inhibitory killer immunoglobulin-lik...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Forlenza, Christopher J., Boudreau, Jeanette E., Zheng, Junting, Le Luduec, Jean-Benoît, Chamberlain, Elizabeth, Heller, Glenn, Cheung, Nai-Kong V., Hsu, Katharine C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962735/
https://ncbi.nlm.nih.gov/pubmed/27069083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.64.9558
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