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KIR3DS1 specific D0 domain polymorphisms disrupt KIR3DL1 surface expression and HLA binding()

KIR3DL1 is a polymorphic inhibitory receptor that modulates natural killer cell activity through interacting with HLA-A and HLA-B alleles that carry the Bw4 epitope. Amino acid polymorphisms throughout KIR3DL1 impact receptor surface expression and affinity for HLA. KIR3DL1/S1 encodes inhibitory and...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Mulrooney, Tiernan J., Zhang, Aaron C., Goldgur, Yehuda, Boudreau, Jeanette E., Hsu, Katharine C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506867/
https://ncbi.nlm.nih.gov/pubmed/26109640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500243
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