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KIR3DL1 and HLA-B density and binding calibrate NK education and response to HIV
Natural killer (NK) cells recognize “self” HLA via killer Ig-like receptors (KIR). Homeostatic HLA expression signals for inhibition via KIR, and downregulation of HLA, a common consequence of viral infection, allows NK activation. Like HLA, KIR are highly polymorphic, and allele combinations of the...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868784/ https://ncbi.nlm.nih.gov/pubmed/26962229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502469 |
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