Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars

Using a large-scale “genomic enzymology” approach, we (i) assigned novel ATP-dependent four-carbon acid sugar kinase functions to members of the DUF1537 protein family (domain of unknown function; Pfam families PF07005 and PF17042) and (ii) discovered novel catabolic pathways for d-threonate, l-thre...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Zhang, Xinshuai, Carter, Michael S., Vetting, Matthew W., San Francisco, Brian, Zhao, Suwen, Al-Obaidi, Nawar F., Solbiati, Jose O., Thiaville, Jennifer J., de Crécy-Lagard, Valérie, Jacobson, Matthew P., Almo, Steven C., Gerlt, John A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2016
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961189/
https://ncbi.nlm.nih.gov/pubmed/27402745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605546113
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