An Enzyme Containing the Conserved Domain of Unknown Function DUF62 Acts as a Stereoselective (R(s),S(c))-S-Adenosylmethionine Hydrolase

Homochirality is a signature of biological systems. The essential and ubiquitous cofactor S-adenosyl-l-methionine (SAM) is synthesized in cells from adenosine triphosphate and l-methionine to yield exclusively the (S,S)-SAM diastereomer. (S,S)-SAM plays a crucial role as the primary methyl donor in...

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發表在:Chembiochem
Main Authors: Kornfuehrer, Taylor, Romanowski, Sean, Crécy-Lagard, Valérie, Hanson, Andrew D., Eustáquio, Alessandra S.
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736106/
https://ncbi.nlm.nih.gov/pubmed/32776704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000349
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