Prediction and Biochemical Demonstration of a Catabolic Pathway for the Osmoprotectant Proline Betaine

Through the use of genetic, enzymatic, metabolomic, and structural analyses, we have discovered the catabolic pathway for proline betaine, an osmoprotectant, in Paracoccus denitrificans and Rhodobacter sphaeroides. Genetic and enzymatic analyses showed that several of the key enzymes of the hydroxyp...

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Detalhes bibliográficos
Principais autores: Kumar, Ritesh, Zhao, Suwen, Vetting, Matthew W., Wood, B. McKay, Sakai, Ayano, Cho, Kyuil, Solbiati, José, Almo, Steven C., Sweedler, Jonathan V., Jacobson, Matthew P., Gerlt, John A., Cronan, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950512/
https://ncbi.nlm.nih.gov/pubmed/24520058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00933-13
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