Discovery of new enzymes and metabolic pathways using structure and genome context

Assigning valid functions to proteins identified in genome projects is challenging, with over-prediction and database annotation errors major concerns(1). We, and others(2), are developing computation-guided strategies for functional discovery using “metabolite docking” to experimentally derived(3)...

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Détails bibliographiques
Auteurs principaux: Zhao, Suwen, Kumar, Ritesh, Sakai, Ayano, Vetting, Matthew W., Wood, B. McKay, Brown, Shoshana, Bonanno, Jeffery B., Hillerich, Brandan S., Seidel, Ronald D., Babbitt, Patricia C., Almo, Steven C., Sweedler, Jonathan V., Gerlt, John A., Cronan, John E., Jacobson, Matthew P.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966649/
https://ncbi.nlm.nih.gov/pubmed/24056934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12576
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