Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS

The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is known about how these assemblies modulate reaction kinetics and the ultimate propagation of signals. Here, we reconstitute phosphotyrosine-mediat...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Huang, William Y. C., Yan, Qingrong, Lin, Wan-Chen, Chung, Jean K., Hansen, Scott D., Christensen, Sune M., Tu, Hsiung-Lin, Kuriyan, John, Groves, Jay T.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961118/
https://ncbi.nlm.nih.gov/pubmed/27370798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602602113
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