Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding

Shiga toxin (Stx), an AB(5) toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells whereas LPLs with small head g...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Ailte, Ieva, Lingelem, Anne Berit Dyve, Kavaliauskiene, Simona, Bergan, Jonas, Kvalvaag, Audun Sverre, Myrann, Anne-Grethe, Skotland, Tore, Sandvig, Kirsten
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960542/
https://ncbi.nlm.nih.gov/pubmed/27458147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30336
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