Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding

Shiga toxin (Stx), an AB(5) toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells whereas LPLs with small head g...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Ailte, Ieva, Lingelem, Anne Berit Dyve, Kavaliauskiene, Simona, Bergan, Jonas, Kvalvaag, Audun Sverre, Myrann, Anne-Grethe, Skotland, Tore, Sandvig, Kirsten
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960542/
https://ncbi.nlm.nih.gov/pubmed/27458147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30336
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