Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

Wiskott–Aldrich syndrome (WAS) is caused by loss-of-function mutations in the WASp gene. Decreased cellular responses in WASp-deficient cells have been interpreted to mean that WASp directly regulates these responses in WASp-sufficient cells. Here, we identify an exception to this concept and show t...

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Vydáno v:Nat Commun
Hlavní autoři: Baptista, Marisa A. P., Keszei, Marton, Oliveira, Mariana, Sunahara, Karen K. S., Andersson, John, Dahlberg, Carin I. M., Worth, Austen J., Liedén, Agne, Kuo, I-Chun, Wallin, Robert P. A., Snapper, Scott B., Eidsmo, Liv, Scheynius, Annika, Karlsson, Mikael C. I., Bouma, Gerben, Burns, Siobhan O., Forsell, Mattias N. E., Thrasher, Adrian J., Nylén, Susanne, Westerberg, Lisa S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960314/
https://ncbi.nlm.nih.gov/pubmed/27425374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12175
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