Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

Wiskott–Aldrich syndrome (WAS) is caused by loss-of-function mutations in the WASp gene. Decreased cellular responses in WASp-deficient cells have been interpreted to mean that WASp directly regulates these responses in WASp-sufficient cells. Here, we identify an exception to this concept and show t...

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Publicado no:Nat Commun
Main Authors: Baptista, Marisa A. P., Keszei, Marton, Oliveira, Mariana, Sunahara, Karen K. S., Andersson, John, Dahlberg, Carin I. M., Worth, Austen J., Liedén, Agne, Kuo, I-Chun, Wallin, Robert P. A., Snapper, Scott B., Eidsmo, Liv, Scheynius, Annika, Karlsson, Mikael C. I., Bouma, Gerben, Burns, Siobhan O., Forsell, Mattias N. E., Thrasher, Adrian J., Nylén, Susanne, Westerberg, Lisa S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4960314/
https://ncbi.nlm.nih.gov/pubmed/27425374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12175
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