ABCC3 Genetic Variants are Associated with Postoperative Morphine-induced Respiratory Depression and Morphine Pharmacokinetics in Children

Respiratory depression (RD) is a serious side effect of morphine and detrimental to effective analgesia. We reported that variants of the ATP binding cassette gene ABCC3 (facilitates hepatic morphine metabolite efflux), affect morphine metabolite clearance. In this study of 316 children undergoing t...

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Udgivet i:Pharmacogenomics J
Main Authors: Chidambaran, Vidya, Venkatasubramanian, Raja, Zhang, Xue, Martin, Lisa J., Niu, Jing, Mizuno, Tomoyuki, Fukuda, Tsuyoshi, Meller, Jaroslaw, Vinks, Alexander A., Sadhasivam, Senthilkumar
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959996/
https://ncbi.nlm.nih.gov/pubmed/26810133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2015.98
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