Effect of intercalator and Lewis acid–base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA()

High throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acids A5, A6, and A7 inhibit the producti...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Wynn, Jessica E., Zhang, Wenyu, Tebit, Denis M., Gray, Laurie R., Hammarskjold, Marie-Louise, Rekosh, David, Santos, Webster L.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957400/
https://ncbi.nlm.nih.gov/pubmed/27453773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6MD00171H
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