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Characterization and in vitro activity of a branched peptide boronic acid that interacts with HIV-1 RRE RNA
A branched peptide containing multiple boronic acids was found to bind RRE IIB selectively and inhibit HIV-1 p24 capsid production in a dose-dependent manner. Structure-activity relationship studies revealed that branching in the peptide is crucial for the low micromolar binding towards RRE IIB, and...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4972714/ https://ncbi.nlm.nih.gov/pubmed/27091070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.04.009 |
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