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Targeting folded RNA: A branched peptide boronic acid that binds to a large surface area of HIV-1 RRE RNA()

On-bead high throughput screening of a medium sized (1000–2000 Da) branched peptide boronic acid (BPBA) library consisting of 46,656 unique sequences against HIV-1 RRE RNA generated peptides with binding affinities in the low micromolar range. In particular, BPBA1 had a K(d) of 1.4 µM with RRE IIB,...

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Hlavní autoři: Zhang, Wenyu, Bryson, David I., Crumpton, Jason B., Wynn, Jessica, Santos, Webster L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821739/
https://ncbi.nlm.nih.gov/pubmed/23925474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob41053f
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