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Branched Peptide Boronic Acids (BPBAs): A Novel Mode of Binding Towards RNA

We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46,656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.

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Detalhes bibliográficos
Main Authors: Zhang, Wenyu, Bryson, David I., Crumpton, Jason B., Wynn, Jessica, Santos, Webster L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601739/
https://ncbi.nlm.nih.gov/pubmed/23412370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc00243h
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