Limited Nucleotide Changes in the Rev Response Element (RRE) during HIV-1 Infection Alter Overall Rev-RRE Activity and Rev Multimerization

HIV-1 Rev and the Rev response element (RRE) enable a critical step in the viral replication cycle by facilitating the nuclear export of intron-containing mRNAs, yet their activities have rarely been analyzed in natural infections. This study characterized their genetic and functional variation in a...

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Detalhes bibliográficos
Main Authors: Sloan, Emily A., Kearney, Mary F., Gray, Laurie R., Anastos, Kathryn, Daar, Eric S., Margolick, Joseph, Maldarelli, Frank, Hammarskjold, Marie-Louise, Rekosh, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807272/
https://ncbi.nlm.nih.gov/pubmed/23926352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01392-13
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