Φορτώνει......
CRISPR-Cas9–Mediated Modification of the NOD Mouse Genome With Ptpn22(R619W) Mutation Increases Autoimmune Diabetes
An allelic variant of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), PTPN22(R620W), is strongly associated with type 1 diabetes (T1D) in humans and increases the risk of T1D by two- to fourfold. The NOD mouse is a spontaneous T1D model that shares with humans many genetic pathways contri...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Diabetes |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Diabetes Association
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955979/ https://ncbi.nlm.nih.gov/pubmed/27207523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0061 |
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