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Identifying the functional contribution of the defatty-acylase activity of SIRT6
Mammalian sirtuin 6 (SIRT6) exhibits many pivotal functions and multiple enzymatic activities, but the contribution of each activity to the various functions is unclear. We identified a SIRT6 G60A mutant that possesses efficient defatty-acylase activity, but has significantly decreased deacetylase a...
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| Publicado en: | Nat Chem Biol |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955683/ https://ncbi.nlm.nih.gov/pubmed/27322069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2106 |
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