Identifying the functional contribution of the defatty-acylase activity of SIRT6

Mammalian sirtuin 6 (SIRT6) exhibits many pivotal functions and multiple enzymatic activities, but the contribution of each activity to the various functions is unclear. We identified a SIRT6 G60A mutant that possesses efficient defatty-acylase activity, but has significantly decreased deacetylase a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Chem Biol
Main Authors: Zhang, Xiaoyu, Khan, Saba, Jiang, Hong, Antonyak, Marc A., Chen, Xiao, Spiegelman, Nicole A., Shrimp, Jonathan H., Cerione, Richard A., Lin, Hening
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955683/
https://ncbi.nlm.nih.gov/pubmed/27322069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2106
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