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Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2
SIRT2 is a member of the human sirtuin family of proteins and possesses NAD(+)-dependent lysine deacetylase/deacylase activity. SIRT2 has been implicated in carcinogenesis in various cancers including leukaemia and is considered an attractive target for cancer therapy. Here, we identified NPD11033,...
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| Gepubliceerd in: | Philos Trans R Soc Lond B Biol Sci |
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| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Royal Society
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5915714/ https://ncbi.nlm.nih.gov/pubmed/29685974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2017.0070 |
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