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HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2
The smallest histone deacetylase (HDAC) and the only class IV HDAC member, HDAC11, is reported to regulate immune activation and tumorigenesis, yet its biochemical function is largely unknown. Here we identify HDAC11 as an efficient lysine defatty-acylase that is >10,000-fold more efficient than...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6431144/ https://ncbi.nlm.nih.gov/pubmed/30819897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815365116 |
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