HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2

The smallest histone deacetylase (HDAC) and the only class IV HDAC member, HDAC11, is reported to regulate immune activation and tumorigenesis, yet its biochemical function is largely unknown. Here we identify HDAC11 as an efficient lysine defatty-acylase that is >10,000-fold more efficient than...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Cao, Ji, Sun, Lei, Aramsangtienchai, Pornpun, Spiegelman, Nicole A., Zhang, Xiaoyu, Huang, Weishan, Seto, Edward, Lin, Hening
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431144/
https://ncbi.nlm.nih.gov/pubmed/30819897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815365116
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