HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2

The smallest histone deacetylase (HDAC) and the only class IV HDAC member, HDAC11, is reported to regulate immune activation and tumorigenesis, yet its biochemical function is largely unknown. Here we identify HDAC11 as an efficient lysine defatty-acylase that is >10,000-fold more efficient than...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Cao, Ji, Sun, Lei, Aramsangtienchai, Pornpun, Spiegelman, Nicole A., Zhang, Xiaoyu, Huang, Weishan, Seto, Edward, Lin, Hening
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431144/
https://ncbi.nlm.nih.gov/pubmed/30819897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815365116
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