Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to discover and develop Ceapins, a class of pyrazole amid...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2016
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954757/
https://ncbi.nlm.nih.gov/pubmed/27435960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11878
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