Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to discover and develop Ceapins, a class of pyrazole amid...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954757/
https://ncbi.nlm.nih.gov/pubmed/27435960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11878
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados