Adaptive Suppression of the ATF4-CHOP Branch of the Unfolded Protein Response by Toll-Like Receptor Signaling

The endoplasmic reticulum (ER) Unfolded Protein Response (UPR) restores equilibrium to the ER, but prolonged expression of the UPR effector CHOP (GADD153) is cytotoxic. We found that ER stress-induced CHOP expression was suppressed by prior engagement of toll-like receptor (TLR) 3 or 4 through a TRI...

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Auteurs principaux: Woo, Connie W., Cui, Dongying, Arellano, Jerry, Dorweiler, Bernhard, Harding, Heather, Fitzgerald, Katherine A., Ron, David, Tabas, Ira
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787632/
https://ncbi.nlm.nih.gov/pubmed/19855386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1996
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