Adaptive Suppression of the ATF4-CHOP Branch of the Unfolded Protein Response by Toll-Like Receptor Signaling

The endoplasmic reticulum (ER) Unfolded Protein Response (UPR) restores equilibrium to the ER, but prolonged expression of the UPR effector CHOP (GADD153) is cytotoxic. We found that ER stress-induced CHOP expression was suppressed by prior engagement of toll-like receptor (TLR) 3 or 4 through a TRI...

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Главные авторы: Woo, Connie W., Cui, Dongying, Arellano, Jerry, Dorweiler, Bernhard, Harding, Heather, Fitzgerald, Katherine A., Ron, David, Tabas, Ira
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787632/
https://ncbi.nlm.nih.gov/pubmed/19855386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1996
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