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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to discover and develop Ceapins, a class of pyrazole amid...
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| Опубликовано в: : | eLife |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4954757/ https://ncbi.nlm.nih.gov/pubmed/27435960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11878 |
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