ω-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation

Elevated levels of the transcriptional regulators Yes-associated protein (YAP) and transcriptional coactivators with PDZ-binding motif (TAZ), key effectors of the Hippo pathway, have been shown to play essential roles in controlling liver cell fate and the activation of hepatic stellate cells (HSCs)...

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Publicado no:Sci Rep
Main Authors: Zhang, Kun, Chang, Yanan, Shi, Zhemin, Han, Xiaohui, Han, Yawei, Yao, Qingbin, Hu, Zhimei, Cui, Hongmei, Zheng, Lina, Han, Tao, Hong, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951777/
https://ncbi.nlm.nih.gov/pubmed/27435808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30029
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